Thiamin biosynthesis: still yielding fascinating biological chemistry
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Thiamin biosynthesis: still yielding fascinating biological chemistry.
The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole s...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2012
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20120084